Read e-book online Advances in neuroregulation and neuroprotection PDF

By Collin, Catherine

ISBN-10: 9047415108

ISBN-13: 9789047415107

ISBN-10: 9067644129

ISBN-13: 9789067644129

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I feel as though my feet were in s a n d . . and I have no solid ground to stand on' — Impressions of an Alzheimer's patient. INTRODUCTION Alzheimer's disease (AD) is an enigma. We have learned much in the last decade about biological markers, genes, and other possible factors relating to the development of this disease, yet there is still much more to understand. , 1968) recognized the disease, not as a rare neurological disorder, but as the most common cause of dementia. AD is a progressive neurologic disease that results in the irreversible loss of neurons in the cerebral cortex and affects about 12 million people worldwide at present (Hy and Keller, 2000).

In fact, detection of vitamin B12 deficiency in humans is a problem to be solved in the clinical area, because data on its levels in blood do not always correlate with CSF levels (Ikeda et aL, 1992). However, there is now good evidence that the majority (>90%) of the 38 G. A. Qureshi et al. patients who are deficient in vitamin B12 accumulate high levels of methylmalonic acid and homocysteine in the blood. Hence, both these substances can be considered a better marker for the clinical diagnosis of vitamin B12 deficiency (Chandefaux etal, 1994).

J. Clin. Lab. Invest. 37, 297-301. Lokk, J. (2003). Treatment with levodopa can effect latent vitamin B12 and folic acid deficiency. Patients with Parkinson disease run the risk of elevated homocysteine levels, Lakatidningen 100, 2674-2677. Playfer, J. R. (1997). Parkinson's disease, Postgrad. Med. J. 73, 257-264. Metz, J. (1992). Cobalamin deficiency and the pathogenesis of nervous system disease, Ann. Ren. Nub. 12, 59-79. Qureshi, G. A. and Baig, S. M. (1988). Quantitation of amino acids in biological samples by HPLC, J.

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Advances in neuroregulation and neuroprotection by Collin, Catherine

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