By Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD ChB DSc
This textbook explores the historical past, biology, and therapy of acid similar illnesses, together with gastric and duodenal ulcer ailment, gastroesophageal reflux illness (GERD), and the function of H. pylori. The textual content deals thorough insurance of the subject material, with an in-depth historic and organic concentration. equivalent concentration is given to the biology and pharmacology of acid secretion and to the categorical affliction states of ulcers and GERD. This version is filled with new full-color scientific illustrations of all features of this topic.
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Additional resources for Acid Related Diseases: Biology and Treatment
From this derives our understanding of stimulation of acid secretion and the processes inhibited by the PPIs. The key structural change in the ion-binding site, apart from sidedness, is the size of the ion it can accommodate. In the “in” conformation, the smaller hydronium ion, H3O+, is accommodated. In the “out” conformation, the smaller ion is weakly bound compared to the larger, partially hydrated K+. Experimental evidence for the reaction cycle described above has been obtained using rapid kinetic analysis of the rate of formation and destruction of phosphoenzyme generated from 32P-ATP at different pH and potassium concentrations.
Smith DL, Tao T, Maguire ME. Membrane topology of a P-type ATPase. The MgtB magnesium transport protein of Salmonella typhimurium. J Biol Chem 1993;268:22469-22479. Smolka A, Helander HF, Sachs G. Monoclonal antibodies against gastric H+,K+ ATPase. Am J Physiol 1983;245:G589. Spallanzani AL. Della digestione degli animali. In: Fisica Animale. Venice, 1782. Spallanzani AL. Dissertazioni de fisica animale e vegetabile. Modena: Società Tipografica, 1780. Stewart B, Wallmark B, Sachs G. The interaction of H+ and K+ with the partial reactions of gastric H,K-ATPase.
J Biol Chem 1990;265:6262-6267. Claros MG, von Heijne G. TopPred II, an improved software for membrane protein structure predictions. Comput Appl Biosci 1994;10:685-686. Celsus AC. Of the disorders of the stomach and their cures. In: De Medicina, book IV. London: Wilson and Durham, 1756:196-201. Griene J, translator. Cyrklaff M, Auer M, Kuhlbrandt W, et al. 2-D structure of the Neurospora crassa plasma membrane ATPase as determined by electron cryomicroscopy. EMBO J 1995;14:1854-1857. Davies RE.
Acid Related Diseases: Biology and Treatment by Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD ChB DSc